今天早上牛津AZ出数据了,有效率70%。Pfizer/BioNTech 和Moderna 95%数据珠玉在前,大家有点小失望。但是70%已经够通过的了。所有接种疫苗后生病的30例里没有一例重症,没有一例需要住院治疗。
比较特别的是,数据显示两针都是‘高剂量’的只有62%有效率,第一针‘低’剂量第二针‘高’剂量可以达到90%。现在不知道为什么。我很好奇的想看看数据,毕竟correlation does not imply causation, 会不会有什么共同的第三因子。
牛津AZ更便宜(£3 vs Pfizer/BioNTech (£15) Moderna(£25),只需要普通冰箱温度,易于存储运输,容易推广到全球各地。
据说英国MHRA一直流水作业的持续审查疫苗安全性数据,有信心很快能批准。
The coronavirus vaccine developed by the University of Oxford stops 70% of people developing Covid symptoms, a large-scale trial shows.
It will be seen as a triumph, but it comes off the back of Pfizer and Moderna showing 95% protection.
However, the Oxford jab is far cheaper, and is easier to store and get to every corner of the world than the other two.
So it will play a significant role in tackling the pandemic, if it is approved by regulators.
There is also intriguing data that suggests perfecting the dose could increase protection up to 90%.
The UK government has pre-ordered 100 million doses of the Oxford vaccine, enough to immunise 50 million people.
Prime Minister Boris Johnson said: "Incredibly exciting news the Oxford vaccine has proved so effective in trials.
"There are still further safety checks ahead, but these are fantastic results."
The vaccine has been developed in around 10 months, a process that normally takes a decade.
"The announcement today takes us another step closer to the time when we can use vaccines to bring an end to the devastation caused by [the virus]," said the vaccine's architect Prof Sarah Gilbert.
What did the trial show?
More than 20,000 volunteers were involved, half in the UK, the rest in Brazil.
There were 30 cases of Covid in people who had two doses of the vaccine and 101 cases in people who received a dummy injection.
The researchers said it works out at 70% protection.
When volunteers were given two "high" doses the protection was 62%, but this rose to 90% when people were given a "low" dose followed by a high one. It's not clear why there is a difference.
"We're really pleased with these results," Prof Andrew Pollard, the trial's lead investigator, told the BBC.
He said the 90% effectiveness data was "intriguing" and would mean "we would have a lot more doses to distribute."
There were also lower levels of asymptomatic infection in the low-followed-by-high-dose group which "means we might be able to halt the virus in its tracks," Prof Pollard said.
Coronavirus vaccine: How close are you to getting one?
When will I get it?
In the UK there are four million doses ready to go, with another 96 million to be delivered.
But nothing can happen until the vaccine has been approved by regulators who will assess the vaccine's safety, effectiveness, and that it is manufactured to high standard. This process will happen in the coming weeks.
However, the UK is ready to press the go button on an unprecedented mass immunisation campaign that dwarfs either the annual flu or childhood vaccination programmes.
Care home residents and staff will be first in the queue, followed by healthcare workers and the over-80s. The plan is to then to work down through the age groups.