一句感慨

入得谷来,祸福自求。
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tiffany
Posts: 23632
Joined: 2003-11-22 20:59

一句感慨

Post by tiffany » 2020-03-20 0:14

最近在做一个癌症药的宣传材料,呃,其实应该叫做教育和医学交流材料。结果这种癌症就很没得治,扩散以后用药中位存活期是一年半多,中位无进展存活期是4个多月,不到5个月的样子。我看了半天,就觉得,为什么呀?那么辛苦也要争取这一年半。

所谓譬如朝露,去日苦多。

the end
有酒有酒 闲饮东窗

笑嘻嘻
Posts: 21163
Joined: 2003-11-22 18:00

Re: 一句感慨

Post by 笑嘻嘻 » 2020-03-20 0:19

Baby step 吧。先争取这点时间。
云浆未饮结成冰

Knowing
Posts: 32171
Joined: 2003-11-22 20:37

Re: 一句感慨

Post by Knowing » 2020-03-20 1:52

一年多挺多的了,不是很多癌症药也就延三五个月吗?
Nevertheless, she persisted.

CAVA
Posts: 7877
Joined: 2003-12-06 16:55

Re: 一句感慨

Post by CAVA » 2020-03-20 5:30

打个不恰当的比方,家里存有许多卫生纸的人会觉得浪费一卷无所谓,只剩下半卷的人会觉得每张都很珍贵。

Jun
Posts: 25229
Joined: 2003-12-15 11:43

Re: 一句感慨

Post by Jun » 2020-03-20 6:53

这不是说这个药用了给你争取到一年半的时间,实际上光说 overall survival 的数据颇为误导,因为癌症扩散后大部分病人不会马上就死的,也会过一段时间。所以这个 OS 要跟无治疗的 OS 时间对比才知道会令人多活多久,反正没那么长就对了。

如果 progression-free survival 的中位数是四五个月,之后就 progress, 给人延长的寿命大概也就六个月上下吧。

自从 FDA 打开大门之后,很多癌症药都不需要在双盲安慰剂对照的临床试验里考验,试验人数也根本很少,跟不治疗的比较借用历史数据。很多被批准的癌症药的疗效其实连一个月都多不出来,照样上市,还很高价。

This is a huge can of worms in American medicine today.
There was nothing to warn anyone about. The world went on, even as it fell apart, changed irrevocably, became something strange and different. --- "Acceptance" in The Southern Reach Trilogy by Jeff VanderMeer

Knowing
Posts: 32171
Joined: 2003-11-22 20:37

Re: 一句感慨

Post by Knowing » 2020-03-20 7:05

这我倒是不太有所谓。没准研究抗癌药过程中发现点别的啥呢。青霉素不也是意外顺便发现的吗。当年美苏军备竞赛浪费的经费哺育了多少后来的重大科研成果。癌症晚期病人多活一个月也是好事,最后半张卫生纸嘛。
有个记者愤怒的说,现在你们都哭着喊着要生物制药专家找出解决方案了?你们付足球明星每月一百万,付生物学家每月一千四百欧。让梅西给你研究新药去!
Nevertheless, she persisted.

Jun
Posts: 25229
Joined: 2003-12-15 11:43

Re: 一句感慨

Post by Jun » 2020-03-20 7:10

You wouldn't say that if you knew how much money infectious disease research gets compared with this kind of cancer research.
There was nothing to warn anyone about. The world went on, even as it fell apart, changed irrevocably, became something strange and different. --- "Acceptance" in The Southern Reach Trilogy by Jeff VanderMeer

Knowing
Posts: 32171
Joined: 2003-11-22 20:37

Re: 一句感慨

Post by Knowing » 2020-03-20 7:12

infectious disease either doesn't kill enough or kills too quickly.....
Nevertheless, she persisted.

tiffany
Posts: 23632
Joined: 2003-11-22 20:59

Re: 一句感慨

Post by tiffany » 2020-03-21 14:41

地水仙开了,风信子开了,第一朵们还在开,牡丹打花骨朵了。人间世还是有可期待的东西的。
有酒有酒 闲饮东窗

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